Decker (Ber., 9 5, 38, p. 1144) has found that many ortho substituted quinolines will not combine with methyl iodide owing to steric hindrance, but the difficulty can be overcome in most cases by using methyl sulphate and heating the reaction components to ioo C. for half an hour.
However, steric hindrance is not fully considered in this Version of the Programs for KIND 10 atoms.
Since there are many steric clashes, we will need to run a short minimisation of this structure before starting molecular dynamics.
Furthermore more work needs to be done to settle the dispute whether atomic interaction lines can also indicate steric interactions [83 ].
The La and Sr cause steric effects due to their very large clouds.