If it doesn't bead up, you'll need to reseal it.
Winemakers would then reseal the cask by means of a special peg.
I like to use the Zip Lock Handy lock system; it takes all the air out and keeps your from getting any freezer burn, and you can reseal them each time.
Respironics CPAP addresses troublesome leaks, and the device lessens pressure to reseal the mask to the sleeper's face rather than increasing the pressure to compensate for the leak.
If you're cartridge has foil don't peel it all the way off as it is needed to reseal the hole.