He made his home with his elder brother Piero at Florence throughout the agitation of Savonarola and the invasion of Charles VIII.
While he was engaged upon some pieces for the convent of the Dominican friars, he made the acquaintance of Savonarola, who quickly acquired great influence over him, and Bartolommeo was so affected by his cruel death, that he soon after entered the convent, and for some years gave up his art.
At this crisis she was ruled by the monk Girolamo Savonarola, who inspired the people with a thirst for freedom, preached the necessity of reformation, and placed himself in direct antagonism to Rome.
After leaving Rome he again lived a wandering life, often visiting Florence, to which he was drawn by his friends Politian and Marsilius Ficinus, and where also he came under the influence of Savonarola.
The story of Alexander's relations with Savonarola is narrated under the latter heading; it is sufficient to say here that the pope's hostility was due to the friar's outspoken invectives against papal corruption and to his appeals for a General Council.