On the 22nd of October 1715 Alexius' consort, the princess Charlotte, died, after giving birth to a son, the grand-duke Peter, afterwards Peter II.
On the 18th of February a "confession" was extorted from Alexius which implicated most of his friends, and he then publicly renounced the succession to the throne in favour of the baby grand-duke Peter Petrovich.
These decrees were issued together with a pastoral letter of Bishop de' Ricci, and were warmly approved by the grand-duke, at whose instance a national synod of the Tuscan bishops met at Florence on the 23rd of April 1787.
On being liberated he returned to Tuscany, and the grand duke Leopold II, knowing that he was popular with the masses, sent him to Leghorn to quell the disturbances.
He accepted, and on the Toth of January 1849, induced the grand duke to establish a national constituent assembly.