When pathological GH excess occurs before epiphyseal fusion in the long bone, the condition is known as gigantism.
What causes gigantism and dwarfism among many species arriving on oceanic islands such as the Seychelles?
Overproduction of hGH or IGH-I, or an exaggerated response to these hormones, can lead to gigantism or acromegaly, both of which are characterized by a very large stature.
Gigantism is the result of hGH overproduction in early childhood leading to a skeletal height up to 8 feet (2.5 m) or more.
The somatotropin test also aids in documenting the excess hGH production responsible for gigantism or acromegaly, and confirms underactivity or overproduction of the pituitary gland (hypopituitarism or hyperpituitarism, respectively).