The wave of change (nervous impulse) induced in a neuron by advent of a stimulus is after all only a sudden augmentation of an activity continuous within the neuron - a transient accentuation of one (the disintegrative) phase of the metabolism inherent in and inseparable from its life.
The long-continued incitement to catabolism of the waking day thus of itself predisposes the nerve cells towards rebound into the opposite phase; the increased catabolism due to the day's stimuli induces increase of anabolism, and though recuperation goes on to a large extent during the day itself, the recuperative process is slower than, and lags behind, the disintegrative.
is to say, if an animal be treated with injections of these bodies, its serum acquires the power of dissolving or of producing some disintegrative effect in them.
The non-sensitiveness of a cell to a toxic body when brought into immediate relationship cannot, however, be explained further than by saying that the disintegrative changes which underlie symptoms of poisoning are not brought about.
Childhood disintegrative disorder is extremely rare, relative to the other pervasive developmental disorders.