A large lethal dose kills by this action, but the minimum lethal dose by its combined action on the respiration and the heart.
In medicine antipyrine ("phenazonum") has been used as an analgesic and antipyretic. The dose is 5-20 grs., but on account of its depressant action on the heart, and the toxic effects to which it occasionally gives rise, it is now but little used.
The sudden withdrawal of the drug from a morphine habitué is followed by a train of alarming symptoms. As the time approaches for the usual dose there is marked restlessness, followed by excitement and later by chills, pallor, sinking, nausea, with perhaps vomiting and diarrhoea.
The volatile oil - oleum cubebae - is also official, and is the form in which this drug is most commonly used, the dose being 5 to 20 minims, which may be suspended in mucilage or given after meals in a cachet.